8 Balance Hidrico

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8. Balance Hídrico CAP 52 Fig 10 Fig 13 Fig 1 Fig 7 Fig 3 Fig 13 Fig 5 Fig 6 KIDNEYS Nick Milne School of Anatomy and Human Biology UWA ã Ontogeny recapitulates…
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8. Balance Hídrico CAP 52 Fig 10 Fig 13 Fig 1 Fig 7 Fig 3 Fig 13 Fig 5 Fig 6 KIDNEYS Nick Milne School of Anatomy and Human Biology UWA • Ontogeny recapitulates Phylogeny • Early development and evolution of the kidney • Intermediate mesoderm • Pronephros • Mesonephros • Metanephros • Ascent and abnormalities Ontogeny Recapitulates Phylogeny Ernst Haeckel 1860? • Ontogeny is the development of the individual • Phylogeny is the evolution of the species • So this is the idea that during development an organism (or an organ) goes through the same stages as during their evolution. • Consider the Frog • It development retraces the evolution of vertebrates from fish to reptiles • From the tadpole stage This idea should be • Water breathing with tail and no limbs (like a fish) considered as a “Parable” • Rudimentary limbs • Reduction of tail It is not necessarily true • Development of lungs – breathes air but it is a useful idea. • Fully developed limbs, loss of tail moves onto land • To the fully developed frog INTERMEDIATE MESODERM • Mesoderm appears in the 3 week embryo • Paraxial = somites • Intermediate • Lateral plate • Two layers separated by the Coelome • Intermediate mesoderm gives rise to “Paired Glands” (Kidneys, Adrenals and Gonads) Pronephros the first kidney • A cavity, like the coelom develops inside the intermediate mesoderm • Balls of bloods vessels from the aorta bulge into the space – The Glomerulus. • The glomerulus allows excess water to leave the blood while  Initially the water filters into the coelom salts and macromolecules are  Later, part of the cavity inside the intermediate retained. mesoderm links up with similar parts in adjacent segments to form a duct. • This kind of kidney is found in primitive fish (eg Lampreys) and in the embryos of most vertebrates Pronephros – in humans • Appears at Day 21 • In segmented intermediate mesoderm in the cervical region • It degenerates by day 24 • It is never functional in humans Mesonephros – middle kidney • When some primitive fish returned to the sea they had the reverse osmotic problem, water tended to diffuse out of their blood. • They developed the mesonephric kidney located in the thoracic region. • The mesonephros had a smaller glomerulus but a larger system of tubules so that the filtration part was reduced and the reabsorbing part was increased. • This was an important preadaption to life on the land where drying out is a constant problem. • Many bony fish and some amphibians have a mesonephric kidney. • The tubules all connect with the mesonephric (Wolfian) duct. Mesonephros - in humans • The Mesonephros first appears early in week 4 • In thoracic and lumbar segments of intermediate mesoderm. • Urine is produced and drains along the mesonephric (Wolfian) duct to the cloaca/bladder • In week 5 the thoracic segments regress but the mesonephric kidney continues functioning until week 10 Fate of the Mesonephric (Wolfian) ducts • The development of the metanephric kidney accompanied the changes in the reproductive system. • The gonads of primitive vertebrates release their eggs and sperm into the coelom, from there they pass via small pores into the cloaca. • In higher vertebrates the eggs are still released into the coelom, but the cloacal pores have become specialised tubes which open adjacent to the ovary. • In the embryo, this egg collecting tube (paramesonephric duct) lies parallel to the mesonephric duct. Male and Female genital ducts • Initially both sexes have both mesonephric and paramesonephric ducts • In females • Eggs are still released into the coelom (peritoneal cavity) but are gathered up in the uterine tubes. • The two paramesonephric ducts become the uterine tubes. • Distally the paramesonephric ducts fuse together to form the uterus and vagina. • The mesonephric duct degenerates completely. • In higher vertebrates sperm is never released into the coelom but reaches the outside by passing through some derivative of the urinary system. In birds, reptiles and mammals the testis develops a connection with the mesonephric duct (at the time that the mesonephros is degenerating). • In males • The mesonephric duct becomes the ductus deferens, seminal vesicle and parts of the prostate gland. • The paramesonephric duct degenerates completely. Metanephros – definitive kidney • The metanephros or definitive kidney of higher vertebrates, begins when the metanephric ducts (ureteric buds) sprout from the distal end of the mesonephric duct at about 5 weeks. • The ureteric buds induce intermediate mesoderm in the sacral region to form a metanephric blastema which forms the glomeruli and tubules of the nephrons. Evolution of the Kidneys: Metanephros • The ureteric buds bifurcate again and again to form the calyces and collecting duct system of the definitive kidney. • The kidneys begin producing urine by week 12, and it adds to the volume of the amniotic fluid. The fetus drinks this fluid in utero. • The fetal kidneys are not responsible for excretion as the placenta serves this function Ascent of the Kidneys • In the 6th week the kidneys begin to ascend from the sacral region to their position in the upper abdomen. • The metanephric ducts elongate and become the ureters. • As the kidney ascends it receives new segmental arteries from the aorta and loses those vessels below (“climbing a ladder”). Thus sometimes there is more than one renal artery. • Sometimes one kidney fails to ascend => pelvic kidney • Sometimes the left and right kidneys become attached in the pelvis then the horseshoe kidney can’t ascend above the inferior mesenteric artery Position of kidneys • Kidneys lie on the psoas muscle beside the vertebral bodies. • The diaphragm and 11th and 12th ribs lie behind the upper half of each kidney. • Therefore they move with breathing • Left is higher than right (liver) • Upper poles T12 • Hilum is at L1/2 • Lower poles at L3 • Upper poles are more medial (psoas). • In the hilum: • Renal vein is the most anterior. It crosses the aorta • Followed by renal artery & pelvis/ureter Is crossed by the SMA • Note that the left renal vein is longer . Receives left gonadal vein Anterior relations • Right • Left • Adrenal • Adrenal • Liver • bare area • Hepatorenal • Stomach pouch • Duodenum • Spleen • Pancreas • Pancreas • Right colic • Descendin flexure g Colon • Jenunum • Jenunum Lecture summary • Early development and evolution • Pronephros • Mesonephros • Metanephros • Ascent and abnormalities • Position and relations • Lobes and segments Orientation and surroundings • The medial border of each kidney is anterior to the lateral border (psoas). Thus the coronal plane of the kidney is at 30 degrees to the coronal plane of the body. • Layers surrounding the kidney • Outside the renal capsule is perirenal fat • Then is the renal fascia which also surrounds the adrenals • This is embedded in extraperitoneal fat (pararenal fat) Renal Lobes and their papillae/calyces • There are 14 lobes originally • Each lobe corresponds with a renal pyramid (plus its cap of cortex), and empties via its papilla, into a minor calyx • Lobes fuse so that there are between 14 and 6, usually 8 (26%) • Most fusion happens at the upper and lower poles so that those papillae are compound. • Simple papillae have valve-like slits where the ducts open – Non-refluxing • Compound papillae allow reflux • Vescicouretal reflux occurs in children and if the urine can enter the parenchyma of the kidney it causes infection and damage 5 Segments of the Kidney • Each segment is the area supplied one branch of the renal artery. (end arteries) • The front of the kidneys has four segments: apical, upper anterior, middle anterior, lower • The back of the kidney has the posterior segment and the posterior aspects of the apical and lower. • Easy way to remember: like your hand holding a glass four fingers in front and the thumb behind. • The posterior branch of the artery branches off first and passes over the renal pelvis to reach the posterior aspect. The four anterior branches continue in the plane between the vein and renal pelvis. Sistema Urinario http://www.123rf.com/photo 6359751 female-highligh http://www.sciencephoto.com/image/418094/530wm/F0040760-Hu ted-urinary-system.html man urinary system, artwork-SPL.jpg Reciben 1,25 l / min – 25% del débito cardíaco Se producen entre 1,42 y 2,9 litros de orina por día (sudoración y respiración) E.Cubillos Funciones http://www.elrincondelamedicinainterna .com/2011 09 25 archive.html http://intranet.tdmu.edu.ua/data/kafedra/internal/distance/lectur es stud/English/1%20course/Pathological%20Physiology/%E2%84%9608. Physiopathology%20of%20kidney%20insufficiency..htm  Regulación de la composición iónica de la sangre: concentración de Na+, Mg2+, K+, Ca2+, Cl- y fosfato (HPO42-)  Mantenimiento de la osmolaridad de la sangre: agua y solutos. Hormona Antidiurética (ADH) producida en el Hipotálamo y liberada por la Hipófisis posterior (Neurohipófisis)  Regulación del volumen de la sangre: los riñones conservan o eliminan agua E.Cubillos  Regulación de la presión sanguínea: ajustando el volumen de sangre en el cuerpo, ajustando el flujo de sangre que entra y sale de los riñones (resistencia renal – resistencia vascular) y mediante la acción de la enzima renina, la que activa el sistema angiotensina – aldosterona  Regulación del pH sanguíneo: excreción de cantidades de hidrogeniones (H+) y retención de iones bicarbonato (HCO3-) E.Cubillos http://www.merckmanuals.com/home/heart and blood vessel diso rders/high blood pressure/high blood pressure.html Sistema Urinario http://www.mille-soeren.dk/20 du kan redde liv /20a anatomy pictures/27 Urinary System Anteri or View.jpg http://www.infogen.org.mx/Infogen1/servlet/CtrlVerArt?clvart=9409 E.Cubillos Órganos Riñón Anatomía externa  Hilio renal  Cápsula renal: membrana lisa, transparente y rugosa, barrera contra traumatismos y da forma al riñón  Cápsula adiposa: tejido graso, protección contra golpes  Aponeurosis renal: tejido conectivo denso e irregular, fijación a la pared abdominal E.Cubillos Riñón Anatomía interna  Corteza Renal: columnas renales o de Bertin  Médula renal: pirámides renales, papilas renales  Cálices mayores (2-3) y menores (5-11)  Pelvis renal E.Cubillos Nefronas: corticales y yuxtamedulares 1.200.000 Elementos: Corpúsculo renal y Túbulo renal E.Cubillos A. Glomérulo Renal E.Cubillos B. Cápsula de Bowman 2. Capa Visceral E.Cubillos Sistema Renina – Angiotensina - Aldosterona http://www.cvphysiology.com/Blood%20Pressure/BP015.htm E.Cubillos Control de la Presión Arterial Sistema Renina – Angiotensina - Aldosterona http://high-blood-pressure-hypertension.knoji.com/how-the-kidneys-control-blood-pressure/ Control de la Presión Arterial E.Cubillos Presión Neta de Filtración  Presión Neta de Filtración (Pnf)  Presión Hidrostática Capilar Glomerular (Pcg)  Presión del Espacio de Bowman (Peb)  Presión Coloidosmótica del Capilar Glomerular (ncg) Pnf = Pcg - Peb - ncg Pnf = 60 mm Hg - 32 mm Hg – 18 mm Hg Pnf = 10 mm Hg TALLER Describe osmosis and explain the terms hypertonic, hypotonic, and isotonic. See p. 116 and Figure 6.10 Homeóstasis Excreción animal Invertebrados Invertebrados Vertebrados Mamíferos Mamíferos Regulación
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